AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in October 2025 (see full year).

Return flights

12 Oct - 05 Nov	Avianca
07 Oct - 11 Oct	Copa	direct
08 Oct - 11 Oct	Copa	direct
09 Oct - 16 Oct	Copa	direct
03 Oct - 07 Oct	Copa	direct
10 Oct - 13 Oct	Copa	direct
10 Oct - 16 Oct	Copa	direct
10 Oct - 17 Oct	Copa	direct
12 Oct - 05 Nov	Copa	direct
22 Oct - 25 Oct	Avianca
14 Oct - 18 Oct	Avianca
14 Oct - 17 Oct	Avianca
30 Oct - 03 Nov	Avianca
31 Oct - 04 Nov	Avianca
30 Oct - 03 Nov	Copa	direct
31 Oct - 04 Nov	Copa	direct

Also check the deals for one-way flights from Quito to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in October from $448

Return flights