AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in December 2025 (see full year).

Return flights

01 Dec - 01 Jan	Avianca
08 Dec - 12 Dec	Avianca
05 Dec - 07 Dec	Avianca
20 Dec - 24 Dec	Avianca
15 Dec - 18 Dec	Avianca
24 Dec - 28 Dec	Avianca
17 Dec - 12 Jan	Copa	direct
15 Dec - 12 Jan	Copa	direct
15 Dec - 28 Dec	Avianca
21 Dec - 01 Jan	Avianca
15 Dec - 28 Dec	Copa	direct
08 Dec - 12 Dec	Copa	direct
20 Dec - 24 Dec	Copa	direct
15 Dec - 18 Dec	Copa	direct
21 Dec - 01 Jan	Copa	direct
19 Dec - 02 Jan	Copa	direct
01 Dec - 01 Jan	Copa	direct
20 Dec - 01 Jan	Avianca
29 Dec - 03 Jan	Copa	direct
20 Dec - 01 Jan	Copa	direct

Also check the deals for one-way flights from Quito to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in December from $468

Return flights