AirHint found the following cheapest return flights from Quito (UIO) to Panama City (PTY) in April 2026 (see full year).

Return flights

18 Apr - 24 Apr	Avianca
17 Apr - 20 Apr	Avianca
08 Apr - 12 Apr	Avianca
11 Apr - 25 Apr	Avianca
27 Apr - 03 May	Avianca
27 Apr - 01 May	Avianca
01 Apr - 05 Apr	Copa	direct
18 Apr - 24 Apr	Copa	direct
08 Apr - 12 Apr	Copa	direct
11 Apr - 25 Apr	Copa	direct
17 Apr - 20 Apr	Copa	direct
06 Apr - 10 Apr	Copa	direct
27 Apr - 03 May	Copa	direct
27 Apr - 04 May	Copa	direct
27 Apr - 01 May	Copa	direct

Also check the deals for one-way flights from Quito to Panama City in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Panama City in April from $303

Return flights