AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in October 2025 (see full year).

Return flights

08 Oct - 22 Oct	JetSmart
08 Oct - 24 Oct	JetSmart
08 Oct - 12 Oct	JetSmart
08 Oct - 15 Oct	JetSmart
22 Oct - 24 Oct	JetSmart
17 Oct - 22 Oct	JetSmart
29 Oct - 19 Nov	JetSmart
12 Oct - 22 Oct	JetSmart
01 Oct - 22 Oct	JetSmart
17 Oct - 24 Oct	JetSmart
03 Oct - 22 Oct	JetSmart
29 Oct - 12 Nov	JetSmart
22 Oct - 12 Nov	JetSmart
29 Oct - 09 Nov	JetSmart
26 Oct - 12 Nov	JetSmart
22 Oct - 09 Nov	JetSmart
29 Oct - 05 Nov	JetSmart
26 Oct - 09 Nov	JetSmart
24 Oct - 12 Nov	JetSmart
22 Oct - 05 Nov	JetSmart

Also check the deals for one-way flights from Quito to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in October from $298

Return flights