AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in November 2025 (see full year).

Return flights

28 Nov - 03 Dec	JetSmart
19 Nov - 03 Dec	JetSmart
05 Nov - 19 Nov	JetSmart
28 Nov - 10 Dec	JetSmart
28 Nov - 07 Dec	JetSmart
19 Nov - 10 Dec	JetSmart
05 Nov - 12 Nov	JetSmart
19 Nov - 07 Dec	JetSmart
19 Nov - 21 Nov	JetSmart
07 Nov - 19 Nov	JetSmart
05 Nov - 21 Nov	JetSmart
05 Nov - 09 Nov	JetSmart
07 Nov - 12 Nov	JetSmart
07 Nov - 21 Nov	JetSmart
07 Nov - 09 Nov	JetSmart
14 Nov - 20 Nov	Avianca
28 Nov - 08 Dec	JetSmart
21 Nov - 02 Dec	Avianca

Also check the deals for one-way flights from Quito to Santiago in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in November from $326

Return flights