AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in December 2025 (see full year).

Return flights

24 Dec - 14 Jan	JetSmart
14 Dec - 24 Dec	JetSmart
17 Dec - 24 Dec	JetSmart
03 Dec - 07 Dec	JetSmart
10 Dec - 12 Dec	JetSmart
03 Dec - 12 Dec	JetSmart
10 Dec - 24 Dec	JetSmart
03 Dec - 24 Dec	JetSmart
24 Dec - 10 Jan	JetSmart
03 Dec - 05 Dec	JetSmart
17 Dec - 07 Jan	JetSmart
17 Dec - 06 Jan	JetSmart
24 Dec - 06 Jan	JetSmart
19 Dec - 24 Dec	JetSmart
24 Dec - 11 Jan	JetSmart
19 Dec - 07 Jan	JetSmart
19 Dec - 06 Jan	JetSmart
10 Dec - 14 Dec	LATAM Airlines Group
14 Dec - 01 Jan	JetSmart
17 Dec - 01 Jan	JetSmart

Also check the deals for one-way flights from Quito to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in December from $392

Return flights