AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in December 2025 (see full year).

Return flights

21 Dec - 28 Jan	JetSmart
31 Dec - 21 Jan	JetSmart
31 Dec - 16 Jan	JetSmart
28 Dec - 16 Jan	JetSmart
31 Dec - 20 Jan	JetSmart
20 Dec - 20 Jan	Avianca
26 Dec - 16 Jan	JetSmart
31 Dec - 13 Jan	JetSmart
28 Dec - 13 Jan	JetSmart
24 Dec - 13 Jan	JetSmart
17 Dec - 31 Dec	JetSmart
17 Dec - 30 Dec	JetSmart
24 Dec - 31 Dec	Avianca
21 Dec - 30 Dec	JetSmart
14 Dec - 30 Dec	Avianca
20 Dec - 28 Dec	Avianca
26 Dec - 31 Dec	JetSmart
21 Dec - 28 Dec	JetSmart
21 Dec - 29 Dec	JetSmart
18 Dec - 21 Dec	Avianca

Also check the deals for one-way flights from Quito to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in December from $425

Return flights