AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in May 2026 (see full year).

Return flights

15 May - 20 May	JetSmart
15 May - 03 Jun	JetSmart
13 May - 03 Jun	JetSmart
13 May - 20 May	JetSmart
15 May - 31 May	JetSmart
20 May - 03 Jun	JetSmart
24 May - 31 May	JetSmart
13 May - 31 May	JetSmart
20 May - 31 May	JetSmart
24 May - 03 Jun	JetSmart
08 May - 23 May	JetSmart
26 May - 31 May	Avianca
26 May - 01 Jun	Avianca
26 May - 02 Jun	Avianca
05 May - 12 May	Avianca

Also check the deals for one-way flights from Quito to Santiago in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in May from $320

Return flights