AirHint found the following cheapest return flights from Quito (UIO) to Santiago (SCL) in September 2025 (see full year).

Return flights

10 Sep - 21 Sep	JetSmart
24 Sep - 08 Oct	JetSmart
14 Sep - 21 Sep	JetSmart
05 Sep - 21 Sep	JetSmart
07 Sep - 21 Sep	JetSmart
24 Sep - 10 Oct	JetSmart
04 Sep - 26 Sep	Copa
10 Sep - 14 Sep	JetSmart
14 Sep - 18 Sep	Avianca
05 Sep - 14 Sep	JetSmart
07 Sep - 14 Sep	JetSmart
20 Sep - 22 Sep	LATAM Airlines Group

Also check the deals for one-way flights from Quito to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Santiago in September from $344

Return flights