Cheapest one-way flights from Cartagena to Madrid in December from $439

Best time to book flights for Cartagena (CTG) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Cartagena (CTG) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

15 Dec Plus Ultra Lineas Aereas direct
17 Dec Plus Ultra Lineas Aereas direct
10 Dec Plus Ultra Lineas Aereas direct
01 Dec Plus Ultra Lineas Aereas direct
03 Dec Plus Ultra Lineas Aereas direct
06 Dec Plus Ultra Lineas Aereas direct
24 Dec Plus Ultra Lineas Aereas direct
05 Dec KLM
02 Dec KLM
20 Dec Plus Ultra Lineas Aereas direct

Also check the deals for return flights from Cartagena to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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