AirHint found the following cheapest return flights from Cartagena (CTG) to Madrid (MAD) in December 2025 (see full year).

Return flights

11 Dec - 28 Jan	KLM
24 Dec - 22 Jan	KLM
24 Dec - 21 Jan	KLM
12 Dec - 19 Jan	KLM
16 Dec - 31 Jan	KLM
13 Dec - 19 Jan	KLM
10 Dec - 21 Jan	KLM
29 Dec - 21 Jan	KLM
29 Dec - 24 Jan	KLM
04 Dec - 23 Jan	KLM
05 Dec - 12 Dec	Spirit Airlines
24 Dec - 31 Dec	KLM
23 Dec - 30 Dec	KLM
03 Dec - 10 Dec	Plus Ultra Lineas Aereas
13 Dec - 30 Dec	KLM
10 Dec - 31 Dec	Avianca
05 Dec - 08 Dec	Spirit Airlines
03 Dec - 13 Dec	Avianca
07 Dec - 14 Dec	JetSmart
01 Dec - 12 Dec	Avianca

Also check the deals for one-way flights from Cartagena to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cartagena to Madrid in December from $633

Return flights