AirHint found the following cheapest one-way flights from Denver (DEN) to Rome (FCO) in September 2025 (see full year).

One-Way flights

15 Sep	Frontier Airlines
14 Sep	Frontier Airlines
28 Sep	Frontier Airlines
27 Sep	Frontier Airlines
19 Sep	Frontier Airlines
24 Sep	Frontier Airlines
25 Sep	Frontier Airlines
13 Sep	Frontier Airlines
22 Sep	Frontier Airlines
21 Sep	Frontier Airlines

Also check the deals for return flights from Denver to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Denver to Rome in September from $222

One-Way flights