AirHint found the following cheapest one-way flights from Rome (FCO) to Sao Paulo (GRU) in September 2025 (see full year).

One-Way flights

23 Sep	Transavia France
24 Sep	Condor
21 Sep	Transavia France
22 Sep	Ryanair
21 Sep	ITA Airways	direct
25 Sep	ITA Airways	direct
20 Sep	ITA Airways	direct
29 Sep	ITA Airways	direct
22 Sep	ITA Airways	direct

Also check the deals for return flights from Rome to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Rome to Sao Paulo in September from $540

One-Way flights