AirHint found the following cheapest return flights from Rome (FCO) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

25 Sep - 07 Oct	ITA Airways	direct
25 Sep - 08 Oct	ITA Airways	direct
22 Sep - 17 Oct	ITA Airways	direct
25 Sep - 18 Oct	ITA Airways	direct
25 Sep - 05 Oct	Delta
27 Sep - 15 Oct	ITA Airways	direct
22 Sep - 29 Sep	Delta
23 Sep - 29 Sep	Delta
22 Sep - 28 Sep	Delta
27 Sep - 25 Oct	ITA Airways	direct
22 Sep - 06 Oct	Delta
24 Sep - 05 Oct	Delta
23 Sep - 07 Oct	Delta
23 Sep - 30 Sep	Delta
22 Sep - 23 Sep	Delta
25 Sep - 30 Sep	Delta
21 Sep - 22 Sep	Delta
20 Sep - 28 Sep	Delta
26 Sep - 29 Sep	ITA Airways	direct
22 Sep - 28 Sep	ITA Airways	direct

Also check the deals for one-way flights from Rome to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Sao Paulo in September from $764

Return flights