AirHint found the following cheapest return flights from Rome (FCO) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

13 Sep - 28 Sep	TAP
06 Sep - 21 Sep	TAP
06 Sep - 28 Sep	TAP
16 Sep - 23 Sep	TAP
02 Sep - 10 Sep	TAP
17 Sep - 24 Oct	TAP
30 Sep - 28 Oct	TAP
28 Sep - 12 Oct	TAP
10 Sep - 28 Sep	KLM
17 Sep - 28 Sep	Air France
13 Sep - 28 Sep	LATAM Airlines Group	direct
10 Sep - 17 Sep	TAP
01 Sep - 11 Sep	TAP
25 Sep - 06 Oct	TAP
11 Sep - 03 Oct	SWISS
03 Sep - 03 Oct	SWISS
24 Sep - 12 Oct	Air Europa
23 Sep - 12 Oct	Delta
14 Sep - 06 Oct	Delta
25 Sep - 12 Oct	Delta

Also check the deals for one-way flights from Rome to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Sao Paulo in September from $646

Return flights