AirHint found the following cheapest one-way flights from Rome (FCO) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

11 Dec	Norse Atlantic Airways
09 Dec	Norse Atlantic Airways
15 Dec	Norse Atlantic Airways
12 Dec	Norse Atlantic Airways
26 Dec	Ryanair
29 Dec	Iberia For Level
27 Dec	Vueling Airlines
20 Dec	Vueling Airlines
17 Dec	Iberia
21 Dec	Vueling Airlines

Also check the deals for return flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Rome to Santiago in December from $493

One-Way flights