AirHint found the following cheapest return flights from Rome (FCO) to Santiago (SCL) in December 2025 (see full year).

Return flights

15 Dec - 16 Jan	Air Canada
15 Dec - 29 Dec	Air Canada
11 Dec - 25 Dec	Delta
22 Dec - 20 Jan	Air Canada
02 Dec - 16 Dec	LATAM Airlines Group
22 Dec - 25 Jan	Air Canada
15 Dec - 15 Jan	Delta
15 Dec - 26 Jan	Delta
06 Dec - 25 Jan	Delta
15 Dec - 17 Jan	Iberia
26 Dec - 06 Jan	Iberia
24 Dec - 06 Jan	Iberia
26 Dec - 03 Jan	Iberia

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from $841

Return flights