AirHint found the following cheapest return flights from Rome (FCO) to Santiago (SCL) in December 2025 (see full year).

Return flights

24 Dec - 26 Jan	Delta
28 Dec - 27 Jan	Delta
24 Dec - 27 Jan	Delta
25 Dec - 27 Jan	Delta
03 Dec - 09 Dec	Delta
08 Dec - 23 Dec	Delta
06 Dec - 24 Jan	Delta
28 Dec - 16 Jan	Delta
23 Dec - 27 Jan	Turkish Airlines
26 Dec - 27 Jan	Delta
24 Dec - 16 Jan	Delta
09 Dec - 13 Jan	Delta
06 Dec - 16 Dec	Delta
09 Dec - 31 Dec	Delta
24 Dec - 31 Dec	Delta
03 Dec - 20 Dec	Ryanair
07 Dec - 20 Dec	Ryanair
12 Dec - 17 Dec	Norse Atlantic Airways
23 Dec - 30 Dec	Turkish Airlines
18 Dec - 23 Dec	Delta

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from $826

Return flights