AirHint found the following cheapest one-way flights from Florence (FLR) to Istanbul (IST) in September 2025 (see full year).

One-Way flights

16 Sep	Vueling Airlines
02 Sep	Aegean Airlines
20 Sep	Aegean Airlines
19 Sep	Air Serbia
06 Sep	Volotea
26 Sep	Air Serbia
12 Sep	Vueling Airlines
30 Sep	Volotea
07 Sep	Vueling Airlines
27 Sep	Aegean Airlines

Also check the deals for return flights from Florence to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Florence to Istanbul in September from $101

One-Way flights