AirHint found the following cheapest return flights from Florence (FLR) to Istanbul (IST) in September 2025 (see full year).

Return flights

16 Sep - 22 Sep	Volotea
09 Sep - 16 Sep	Volotea
19 Sep - 23 Sep	Volotea
17 Sep - 22 Sep	Volotea
09 Sep - 10 Sep	Volotea
22 Sep - 07 Oct	Air France
10 Sep - 24 Sep	Volotea
11 Sep - 15 Sep	Air France
16 Sep - 18 Sep	Volotea
17 Sep - 20 Sep	Volotea
19 Sep - 21 Sep	Volotea
09 Sep - 10 Oct	Air France
28 Sep - 01 Oct	ITA Airways

Also check the deals for one-way flights from Florence to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Florence to Istanbul in September from $221

Return flights