AirHint found the following cheapest one-way flights from Heraklion (HER) to Istanbul (IST) in October 2025 (see full year).

One-Way flights

17 Oct	Aegean Airlines
31 Oct	Aegean Airlines
22 Oct	Aegean Airlines
26 Oct	Aegean Airlines
21 Oct	Aegean Airlines
18 Oct	Aegean Airlines
23 Oct	Aegean Airlines
24 Oct	Aegean Airlines
14 Oct	Aegean Airlines
20 Oct	Aegean Airlines

Also check the deals for return flights from Heraklion to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Heraklion to Istanbul in October from $60

One-Way flights