AirHint found the following cheapest return flights from Heraklion (HER) to Istanbul (IST) in October 2025 (see full year).

Return flights

15 Oct - 20 Oct	Aegean Airlines
09 Oct - 20 Oct	Aegean Airlines
27 Oct - 30 Oct	Aegean Airlines
22 Oct - 27 Oct	Aegean Airlines
25 Oct - 30 Oct	Aegean Airlines
25 Oct - 27 Oct	Aegean Airlines
17 Oct - 20 Oct	Aegean Airlines
16 Oct - 20 Oct	Aegean Airlines
14 Oct - 20 Oct	SKY express
20 Oct - 23 Oct	Aegean Airlines
30 Oct - 03 Nov	Aegean Airlines
27 Oct - 06 Nov	Aegean Airlines

Also check the deals for one-way flights from Heraklion to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Heraklion to Istanbul in October from $120

Return flights