Cheapest one-way flights from Houston to Panama City in December from $232

AirHint found the following cheapest one-way flights from Houston (IAH) to Panama City (PTY) in December 2025 (see full year).

One-Way flights

30 Dec Frontier Airlines
13 Dec Spirit Airlines
28 Dec Spirit Airlines
26 Dec Spirit Airlines
18 Dec Frontier Airlines
20 Dec Spirit Airlines
30 Dec United direct
28 Dec United direct
20 Dec United direct
26 Dec United direct

Also check the deals for return flights from Houston to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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