AirHint found the following cheapest one-way flights from Istanbul (IST) to Sao Paulo (GRU) in December 2025 (see full year).

One-Way flights

29 Dec	Royal Air Maroc
01 Dec	Wizz Air
03 Dec	Royal Air Maroc
02 Dec	Wizz Air UK
06 Dec	Wizz Air UK
05 Dec	Pegasus Airlines
12 Dec	Wizz Air UK
11 Dec	Qatar Airways
18 Dec	Qatar Airways
03 Dec	Turkish Airlines	direct

Also check the deals for return flights from Istanbul to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Istanbul to Sao Paulo in December from $544

One-Way flights