AirHint found the following cheapest return flights from Istanbul (IST) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

02 Dec - 09 Dec	KLM
02 Dec - 11 Dec	KLM
04 Dec - 11 Dec	KLM
01 Dec - 07 Dec	KLM
01 Dec - 08 Dec	KLM
01 Dec - 12 Dec	KLM
02 Dec - 15 Dec	KLM
05 Dec - 15 Dec	KLM
03 Dec - 17 Dec	KLM
02 Dec - 14 Dec	KLM
29 Dec - 23 Jan	KLM
31 Dec - 15 Jan	Air Europa
29 Dec - 16 Jan	Air Europa
29 Dec - 17 Jan	Air Europa
26 Dec - 24 Jan	Air Europa
30 Dec - 02 Jan	Air Europa
23 Dec - 13 Jan	Qatar Airways
19 Dec - 16 Jan	Air Cairo
20 Dec - 16 Jan	Air Cairo
15 Dec - 15 Jan	Turkish Airlines

Also check the deals for one-way flights from Istanbul to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Sao Paulo in December from $810

Return flights