AirHint found the following cheapest return flights from Istanbul (IST) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

28 Dec - 28 Jan	KLM
06 Dec - 13 Dec	Air France
27 Dec - 26 Jan	KLM
23 Dec - 28 Jan	KLM
09 Dec - 16 Dec	Air Europa
26 Dec - 24 Jan	KLM
25 Dec - 24 Jan	KLM
23 Dec - 22 Jan	KLM
28 Dec - 04 Jan	Qatar Airways
25 Dec - 04 Jan	Qatar Airways
26 Dec - 28 Dec	Air Europa
16 Dec - 23 Dec	Air Europa
16 Dec - 31 Dec	Air Europa
08 Dec - 18 Dec	Air Europa
27 Dec - 05 Jan	Qatar Airways
10 Dec - 23 Dec	KLM
25 Dec - 15 Jan	KLM
16 Dec - 22 Dec	Air Europa
10 Dec - 17 Dec	Aegean Airlines
06 Dec - 20 Dec	Air France

Also check the deals for one-way flights from Istanbul to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Sao Paulo in December from $914

Return flights