Cheapest one-way flights from Istanbul to Madrid in December from $73

AirHint found the following cheapest one-way flights from Istanbul (IST) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

16 Dec Pegasus Airlines direct
17 Dec Pegasus Airlines direct
10 Dec Pegasus Airlines direct
14 Dec SKY express
13 Dec Wizz Air Malta
09 Dec Wizz Air UK
03 Dec Pegasus Airlines direct
05 Dec Pegasus Airlines direct
01 Dec Wizz Air UK
02 Dec Pegasus Airlines direct

Also check the deals for return flights from Istanbul to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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