AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in October 2025 (see full year).

One-Way flights

19 Oct	Wizz Air Malta
03 Oct	Pegasus Airlines	direct
12 Oct	Pegasus Airlines	direct
17 Oct	Pegasus Airlines	direct
22 Oct	Pegasus Airlines	direct
23 Oct	Pegasus Airlines	direct
18 Oct	Pegasus Airlines	direct
15 Oct	Pegasus Airlines	direct
14 Oct	Wizz Air Malta
16 Oct	Pegasus Airlines	direct

Also check the deals for return flights from Madrid to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Madrid to Istanbul in October from $81

One-Way flights