AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in October 2025 (see full year).

Return flights

12 Oct - 19 Oct	Pegasus Airlines	direct
04 Oct - 15 Oct	Ryanair
02 Oct - 06 Oct	Wizz Air Malta
02 Oct - 05 Oct	Wizz Air Malta
01 Oct - 06 Oct	Wizz Air Malta
02 Oct - 07 Oct	Wizz Air Malta
02 Oct - 09 Oct	Wizz Air Malta
01 Oct - 08 Oct	Wizz Air Malta
01 Oct - 05 Oct	Wizz Air Malta
11 Oct - 19 Oct	Ryanair
31 Oct - 05 Nov	SKY express
30 Oct - 02 Nov	Ryanair
30 Oct - 15 Nov	Ryanair
06 Oct - 16 Nov	Wizz Air
29 Oct - 04 Nov	easyJet
25 Oct - 09 Nov	Wizz Air Malta
23 Oct - 04 Nov	Wizz Air Malta
26 Oct - 01 Nov	SKY express
27 Oct - 01 Nov	Wizz Air Malta
27 Oct - 12 Nov	Aegean Airlines

Also check the deals for one-way flights from Madrid to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Istanbul in October from $153

Return flights