Cheapest one-way flights from Madrid to Istanbul in December from $89

AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in December 2025 (see full year).

One-Way flights

07 Dec SKY express
03 Dec SKY express
15 Dec SKY express
01 Dec SKY express
11 Dec SKY express
05 Dec SKY express
08 Dec SKY express
09 Dec Pegasus Airlines direct
18 Dec SKY express
17 Dec SKY express

Also check the deals for return flights from Madrid to Istanbul in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul

Feel free to contact us with any feedback or request another flight research.