Cheapest one-way flights from Madrid to Istanbul in December from $81

Best time to book flights for Madrid (MAD) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in December 2025 (see full year).

One-Way flights

10 Dec Pegasus Airlines direct
03 Dec Pegasus Airlines direct
02 Dec Pegasus Airlines direct
05 Dec Pegasus Airlines direct
29 Dec Iberia Express
04 Dec Pegasus Airlines direct
08 Dec Pegasus Airlines direct
19 Dec Aegean Airlines
18 Dec Aegean Airlines
21 Dec Aegean Airlines

Also check the deals for return flights from Madrid to Istanbul in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul