Cheapest one-way flights from Madrid to Istanbul in April from $104

AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in April 2026 (see full year).

One-Way flights

23 Apr Iberia Express
29 Apr Iberia Express
10 Apr Aegean Airlines
02 Apr Aegean Airlines
06 Apr Aegean Airlines
11 Apr Aegean Airlines
29 Apr Air Europa direct
23 Apr Air Europa direct
02 Apr Turkish Airlines direct
11 Apr Turkish Airlines direct

Also check the deals for return flights from Madrid to Istanbul in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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