Cheapest return flights from Madrid to Istanbul in April from $229

AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in April 2026 (see full year).

Return flights

22 Apr - 26 Apr Air Europa
06 Apr - 12 Apr Aegean Airlines
23 Apr - 28 Apr Iberia Express
21 Apr - 27 Apr Iberia Express
18 Apr - 25 Apr Aegean Airlines
03 Apr - 08 Apr Aegean Airlines
09 Apr - 12 Apr Aegean Airlines
01 Apr - 07 Apr Aegean Airlines
14 Apr - 02 May Aegean Airlines
25 Apr - 12 May Lufthansa
14 Apr - 21 Apr Aegean Airlines
27 Apr - 03 May Iberia Express
06 Apr - 10 Apr Aegean Airlines
29 Apr - 03 May Iberia Express
28 Apr - 03 May Iberia
14 Apr - 02 May Air Europa direct
28 Apr - 03 May Air Europa direct
25 Apr - 12 May Air Europa direct
27 Apr - 03 May Air Europa direct

Also check the deals for one-way flights from Madrid to Istanbul in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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