Cheapest return flights from Madrid to Istanbul in April from $321

Best time to book flights for Madrid (MAD) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in April 2026 (see full year).

Return flights

22 Apr - 26 Apr Lufthansa
02 Apr - 07 Apr TAROM
11 Apr - 18 Apr Lufthansa
16 Apr - 19 Apr Lufthansa
16 Apr - 19 Apr Air Europa direct
22 Apr - 26 Apr Air Europa direct
30 Apr - 05 May Air Europa direct
02 Apr - 06 Apr ITA Airways
02 Apr - 06 Apr Turkish Airlines direct
11 Apr - 18 Apr Turkish Airlines direct
04 Apr - 09 Apr TAROM

Also check the deals for one-way flights from Madrid to Istanbul in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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