Cheapest one-way flights from Madrid to Istanbul in May from $117

AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in May 2026 (see full year).

One-Way flights

05 May British Airways
10 May Aegean Airlines
01 May Aegean Airlines
30 May Aegean Airlines
24 May Aegean Airlines
28 May Air Europa
18 May Air Europa
30 May Air Europa direct
28 May Air Europa direct
05 May Air Europa direct

Also check the deals for return flights from Madrid to Istanbul in May.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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