Cheapest one-way flights from Madrid to Istanbul in May from $97
AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in May 2025 (see full year).
One-Way flights
| 17 May | Wizz Air | ||
| 20 May | Wizz Air Malta | ||
| 21 May | Air Europa | ||
| 27 May | Wizz Air | ||
| 25 May | Wizz Air | ||
| 27 May | Pegasus Airlines | direct | |
| 30 May | easyJet | ||
| 29 May | Iberia Express | ||
| 22 May | Air Europa | ||
| 31 May | Wizz Air Malta |
Also check the deals for return flights from Madrid to Istanbul in May.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
