Cheapest return flights from Madrid to Istanbul in May from $192

AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in May 2026 (see full year).

Return flights

06 May - 12 May Air Europa
08 May - 10 May Air Europa
13 May - 17 May Air Europa
08 May - 13 May Iberia Express
09 May - 13 May Air Europa
07 May - 14 May Iberia Express
07 May - 11 May Iberia Express
10 May - 14 May Iberia Express
10 May - 15 May Iberia Express
10 May - 16 May Iberia Express
27 May - 04 Jun Air Europa
30 May - 04 Jun Aegean Airlines
29 May - 04 Jun Aegean Airlines
29 May - 07 Jun Aegean Airlines
30 May - 07 Jun Aegean Airlines
29 May - 05 Jun Aegean Airlines
29 May - 06 Jun Aegean Airlines
29 May - 04 Jun Air Europa direct
29 May - 05 Jun Air Europa direct
29 May - 06 Jun Air Europa direct

Also check the deals for one-way flights from Madrid to Istanbul in May.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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