AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in September 2025 (see full year).

One-Way flights

25 Sep	Pegasus Airlines	direct
26 Sep	Pegasus Airlines	direct
23 Sep	Wizz Air Malta
17 Sep	Pegasus Airlines	direct
09 Sep	Pegasus Airlines	direct
10 Sep	Pegasus Airlines	direct
19 Sep	Pegasus Airlines	direct
12 Sep	Pegasus Airlines	direct
16 Sep	Pegasus Airlines	direct
24 Sep	Wizz Air Malta

Also check the deals for return flights from Madrid to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Madrid to Istanbul in September from $81

One-Way flights