Cheapest return flights from Madrid to Istanbul in September from $188

Best time to book flights for Madrid (MAD) to Istanbul (IST) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in September 2025 (see full year).

Return flights

16 Sep - 24 Sep easyJet
23 Sep - 01 Oct Wizz Air Malta
27 Sep - 09 Oct Wizz Air Malta
09 Sep - 17 Sep easyJet
19 Sep - 01 Oct Ryanair
16 Sep - 22 Sep easyJet
23 Sep - 27 Sep Wizz Air Malta
24 Sep - 01 Oct Ryanair
17 Sep - 24 Sep easyJet
19 Sep - 24 Sep easyJet
03 Sep - 15 Sep easyJet
20 Sep - 26 Sep easyJet
20 Sep - 03 Oct easyJet
25 Sep - 01 Oct easyJet
11 Sep - 20 Sep Wizz Air Malta
29 Sep - 02 Oct Wizz Air
26 Sep - 01 Oct easyJet
25 Sep - 02 Oct easyJet
25 Sep - 03 Oct easyJet
15 Sep - 20 Sep Iberia

Also check the deals for one-way flights from Madrid to Istanbul in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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