Cheapest one-way flights from Madrid to Panama City in November from $557

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in November 2025 (see full year).

One-Way flights

14 Nov Ryanair
17 Nov Ryanair
01 Nov TAP
13 Nov Wizz Air Malta
04 Nov Air Europa direct
01 Nov Air Europa direct
30 Nov Air Europa direct
05 Nov Air Europa direct
29 Nov Air Europa direct
14 Nov Air Europa direct

Also check the deals for return flights from Madrid to Panama City in November.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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