AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in November 2025 (see full year).

Return flights

15 Nov - 26 Nov	United
15 Nov - 25 Nov	United
06 Nov - 23 Nov	United
15 Nov - 24 Nov	United
07 Nov - 17 Nov	United
15 Nov - 28 Nov	United
14 Nov - 24 Nov	United
07 Nov - 16 Nov	United
14 Nov - 23 Nov	United
13 Nov - 23 Nov	United
21 Nov - 01 Dec	United
22 Nov - 06 Dec	Air Europa	direct
22 Nov - 07 Dec	Air Europa	direct
21 Nov - 01 Dec	Air Europa	direct
25 Nov - 02 Dec	Air Europa	direct
22 Nov - 02 Dec	Air Europa	direct
26 Nov - 02 Dec	KLM
29 Nov - 08 Dec	Iberia	direct
30 Nov - 07 Dec	Air Europa	direct
28 Nov - 07 Dec	United

Also check the deals for one-way flights from Madrid to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in November from $682

Return flights