Cheapest one-way flights from Madrid to Panama City in December from $544

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in December 2025 (see full year).

One-Way flights

28 Dec Avianca
10 Dec TAP
10 Dec Iberia direct
20 Dec Ryanair
18 Dec Air Europa direct
19 Dec Air Europa direct
28 Dec Air Europa direct
23 Dec Turkish Airlines
23 Dec Air Europa direct
20 Dec Iberia direct

Also check the deals for return flights from Madrid to Panama City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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