Cheapest return flights from Madrid to Panama City in December from $952

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in December 2025 (see full year).

Return flights

27 Dec - 12 Jan United
07 Dec - 28 Dec KLM
20 Dec - 31 Dec Iberia direct
17 Dec - 30 Dec Air Europa direct
17 Dec - 27 Dec Air Europa direct
06 Dec - 28 Dec United
15 Dec - 05 Jan Iberia direct
24 Dec - 07 Jan Turkish Airlines
24 Dec - 04 Jan Turkish Airlines
26 Dec - 04 Jan Turkish Airlines
31 Dec - 11 Jan United
22 Dec - 05 Jan Iberia direct
11 Dec - 28 Dec KLM
24 Dec - 07 Jan Iberia direct
22 Dec - 25 Jan KLM
27 Dec - 05 Jan Iberia direct
21 Dec - 30 Dec KLM
17 Dec - 31 Dec Air France
20 Dec - 27 Dec Air France

Also check the deals for one-way flights from Madrid to Panama City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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