Cheapest return flights from Madrid to Panama City in December from $889

AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in December 2025 (see full year).

Return flights

04 Dec - 14 Dec Air France
30 Dec - 22 Jan Ryanair
11 Dec - 15 Dec United
05 Dec - 08 Dec Ryanair
05 Dec - 13 Dec United
11 Dec - 14 Dec United
04 Dec - 15 Dec United
05 Dec - 14 Dec United
25 Dec - 30 Dec Air Europa direct
30 Dec - 25 Jan Air Europa direct
14 Dec - 26 Dec United
08 Dec - 24 Dec Iberia direct
06 Dec - 31 Jan Iberia direct
24 Dec - 24 Jan Iberia direct
31 Dec - 11 Jan Ryanair
14 Dec - 19 Jan Air Europa
30 Dec - 22 Jan Air Europa direct
30 Dec - 12 Jan Wizz Air Malta
13 Dec - 12 Jan Air Europa
26 Dec - 20 Jan Royal Air Maroc

Also check the deals for one-way flights from Madrid to Panama City in December.

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