Cheapest one-way flights from Madrid to Panama City in April from $331

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in April 2026 (see full year).

One-Way flights

25 Apr Air Europa direct
23 Apr Air Europa direct
15 Apr Air Europa direct
29 Apr Air Europa direct
14 Apr Air Europa direct
27 Apr Air Europa direct
10 Apr Iberia direct
01 Apr Avianca
03 Apr Avianca
03 Apr Air Europa direct

Also check the deals for return flights from Madrid to Panama City in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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