Cheapest one-way flights from Madrid to Panama City in April from $364

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in April 2026 (see full year).

One-Way flights

24 Apr Avianca
17 Apr Avianca
25 Apr Avianca
16 Apr Avianca
08 Apr Iberia Express
05 Apr Avianca
16 Apr Air Europa direct
25 Apr Air Europa direct
17 Apr Air Europa direct
08 Apr Air Europa direct

Also check the deals for return flights from Madrid to Panama City in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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