Cheapest return flights from Madrid to Panama City in April from $636

AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in April 2026 (see full year).

Return flights

13 Apr - 22 Apr Air Europa direct
15 Apr - 22 Apr Iberia direct
10 Apr - 19 Apr Iberia direct
10 Apr - 22 Apr Iberia direct
13 Apr - 27 Apr Air Europa direct
10 Apr - 24 Apr Iberia direct
19 Apr - 27 Apr Air Europa direct
13 Apr - 19 Apr Air Europa direct
22 Apr - 04 May Air Europa direct
12 Apr - 22 Apr Iberia direct
05 Apr - 19 Apr Iberia direct
19 Apr - 15 May Iberia direct
21 Apr - 03 May Air Europa direct
20 Apr - 03 May Avianca
23 Apr - 08 May Avianca
24 Apr - 01 May Iberia direct
19 Apr - 16 May Air Europa direct
18 Apr - 01 May Avianca
19 Apr - 02 May Iberia
30 Apr - 14 May Air Europa direct

Also check the deals for one-way flights from Madrid to Panama City in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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