Cheapest one-way flights from Madrid to Panama City in September from $330

AirHint found the following cheapest one-way flights from Madrid (MAD) to Panama City (PTY) in September 2025 (see full year).

One-Way flights

14 Sep Air Europa direct
03 Sep Air Europa direct
12 Sep Air Europa direct
04 Sep Air Europa direct
02 Sep Air Europa direct
11 Sep Air Europa direct
06 Sep Air Europa direct
23 Sep TAP
21 Sep Avianca
25 Sep Avianca

Also check the deals for return flights from Madrid to Panama City in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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