Cheapest return flights from Madrid to Panama City in September from $653

Best time to book flights for Madrid (MAD) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in September 2025 (see full year).

Return flights

01 Sep - 11 Sep Air France
11 Sep - 28 Sep KLM
02 Sep - 11 Sep KLM
14 Sep - 27 Sep Air France
16 Sep - 28 Sep KLM
24 Sep - 28 Sep KLM
19 Sep - 04 Oct KLM
15 Sep - 25 Sep KLM
16 Sep - 23 Sep KLM
08 Sep - 29 Sep KLM
01 Sep - 30 Sep KLM
04 Sep - 13 Oct KLM
16 Sep - 01 Oct KLM
22 Sep - 02 Oct KLM
20 Sep - 11 Oct Air France
26 Sep - 05 Oct Air France
19 Sep - 04 Oct Air Europa direct
16 Sep - 01 Oct Air Europa direct
20 Sep - 11 Oct Air Europa direct

Also check the deals for one-way flights from Madrid to Panama City in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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