Cheapest one-way flights from Madrid to Santiago in December from $504
AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).
One-Way flights
| 04 Dec | Azul Airlines | ||
| 08 Dec | Ryanair | ||
| 02 Dec | Ryanair | ||
| 03 Dec | Air Europa | ||
| 12 Dec | Air Europa | ||
| 10 Dec | Air Europa | ||
| 09 Dec | Iberia | ||
| 11 Dec | easyJet | ||
| 06 Dec | Azul Airlines | ||
| 14 Dec | Azul Airlines |
Also check the deals for return flights from Madrid to Santiago in December.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
