Cheapest one-way flights from Madrid to Santiago in December from $546

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

10 Dec Air Europa
31 Dec Avianca
09 Dec Air Europa
03 Dec Air Europa
07 Dec Ryanair
08 Dec Ryanair
13 Dec Air Europa
02 Dec LATAM Airlines Group direct
31 Dec LATAM Airlines Group direct
05 Dec LATAM Airlines Group direct

Also check the deals for return flights from Madrid to Santiago in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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