Cheapest one-way flights from Madrid to Santiago in December from $565

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in December 2026 (see full year).

One-Way flights

01 Dec Air Europa
06 Dec Iberia
25 Dec Iberia
28 Dec Avianca
27 Dec Air Europa
27 Dec LATAM Airlines Group direct
06 Dec LATAM Airlines Group direct
13 Dec LATAM Airlines Group direct
01 Dec LATAM Airlines Group direct
25 Dec LATAM Airlines Group direct

Also check the deals for return flights from Madrid to Santiago in December.

Powered by

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Feel free to contact us with any feedback or request another flight research.