AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

Return flights

07 Dec - 27 Dec	Delta
08 Dec - 29 Jan	Delta
04 Dec - 29 Jan	Delta
04 Dec - 31 Jan	Delta
08 Dec - 22 Dec	Delta
10 Dec - 18 Jan	Delta
07 Dec - 15 Jan	Delta
05 Dec - 18 Jan	Delta
03 Dec - 08 Dec	Delta
08 Dec - 29 Dec	Delta
09 Dec - 29 Dec	Delta
08 Dec - 21 Jan	Delta
08 Dec - 13 Jan	Delta
05 Dec - 12 Dec	Iberia
03 Dec - 15 Dec	Iberia
02 Dec - 15 Dec	Iberia
02 Dec - 09 Dec	Iberia
03 Dec - 12 Dec	Iberia
24 Dec - 15 Jan	Delta
27 Dec - 24 Jan	Delta

Also check the deals for one-way flights from Madrid to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in December from $819

Return flights