AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

Return flights

25 Dec - 22 Jan	Delta
04 Dec - 08 Dec	Delta
05 Dec - 15 Jan	Delta
15 Dec - 28 Dec	Air Canada
15 Dec - 11 Jan	Air Canada
08 Dec - 31 Dec	Air Canada
24 Dec - 15 Jan	Delta
28 Dec - 29 Jan	Delta
25 Dec - 20 Jan	Delta
10 Dec - 28 Dec	Air Canada
01 Dec - 08 Dec	Delta
29 Dec - 20 Jan	Delta
23 Dec - 22 Jan	Delta
08 Dec - 24 Jan	Delta
06 Dec - 15 Jan	Delta
10 Dec - 26 Dec	Air Canada
03 Dec - 10 Dec	TAP
02 Dec - 11 Dec	Royal Air Maroc
12 Dec - 28 Dec	Air Canada
01 Dec - 14 Dec	Lufthansa

Also check the deals for one-way flights from Madrid to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in December from $880

Return flights