AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in December 2025 (see full year).

Return flights

03 Dec - 09 Dec	Delta
10 Dec - 29 Jan	Delta
04 Dec - 20 Jan	Delta
08 Dec - 20 Jan	Delta
10 Dec - 20 Jan	Delta
09 Dec - 27 Jan	Delta
09 Dec - 20 Jan	Delta
05 Dec - 13 Dec	LATAM Airlines Group
30 Dec - 29 Jan	Delta
04 Dec - 08 Dec	Delta
04 Dec - 09 Dec	Delta
03 Dec - 07 Dec	Delta
30 Dec - 31 Jan	Delta
04 Dec - 24 Dec	Delta
10 Dec - 24 Dec	Delta
10 Dec - 18 Jan	Delta
03 Dec - 13 Dec	LATAM Airlines Group
29 Dec - 26 Jan	Delta
25 Dec - 31 Dec	Air Canada
04 Dec - 11 Dec	LATAM Airlines Group

Also check the deals for one-way flights from Madrid to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in December from $816

Return flights