Cheapest one-way flights from Madrid to Santiago in April from $500

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in April 2026 (see full year).

One-Way flights

12 Apr Azul Airlines
09 Apr Azul Airlines
15 Apr Azul Airlines
01 Apr Azul Airlines
07 Apr Ryanair
10 Apr Iberia
08 Apr Iberia
14 Apr LATAM Airlines Group direct
30 Apr LATAM Airlines Group direct
06 Apr LATAM Airlines Group direct

Also check the deals for return flights from Madrid to Santiago in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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