Cheapest one-way flights from Madrid to Santiago in April from $550

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santiago (SCL) in April 2026 (see full year).

One-Way flights

09 Apr Azul Airlines
04 Apr Avianca
12 Apr TAP
18 Apr LATAM Airlines Group direct
17 Apr LATAM Airlines Group direct
13 Apr Iberia
09 Apr LATAM Airlines Group direct
04 Apr LATAM Airlines Group direct
12 Apr LATAM Airlines Group direct
15 Apr LATAM Airlines Group direct

Also check the deals for return flights from Madrid to Santiago in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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