AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in April 2026 (see full year).

Return flights

02 Apr - 08 Apr	LATAM Airlines Group
28 Apr - 12 May	LATAM Airlines Group
02 Apr - 11 Apr	Iberia	direct
01 Apr - 12 Apr	Iberia	direct
07 Apr - 21 Apr	Iberia	direct
01 Apr - 11 Apr	Iberia	direct
01 Apr - 30 Apr	Iberia	direct
08 Apr - 14 Apr	LATAM Airlines Group
01 Apr - 10 Apr	Iberia	direct
01 Apr - 14 May	Iberia	direct
30 Apr - 09 May	Iberia	direct
28 Apr - 12 May	Iberia	direct
29 Apr - 03 May	LATAM Airlines Group
09 Apr - 15 Apr	Azul Airlines
09 Apr - 12 Apr	Azul Airlines
30 Apr - 02 May	Avianca
24 Apr - 05 May	Delta
29 Apr - 03 May	Iberia	direct
30 Apr - 02 May	Iberia	direct

Also check the deals for one-way flights from Madrid to Santiago in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in April from $974

Return flights