Cheapest one-way flights from Madrid to Santa Cruz in October from $537

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in October 2025 (see full year).

One-Way flights

10 Oct LATAM Airlines Group
29 Oct Azul Airlines
03 Oct Azul Airlines
08 Oct Azul Airlines
15 Oct Avianca
15 Oct Air Europa direct
08 Oct Air Europa direct
07 Oct Avianca
17 Oct Avianca
01 Oct Azul Airlines

Also check the deals for return flights from Madrid to Santa Cruz in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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