AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in October 2025 (see full year).

Return flights

04 Oct - 01 Nov	Avianca
10 Oct - 01 Nov	Avianca
05 Oct - 09 Oct	Avianca
03 Oct - 30 Oct	Avianca
26 Oct - 17 Nov	Avianca
31 Oct - 10 Nov	Avianca
01 Oct - 28 Oct	Avianca
07 Oct - 29 Nov	Avianca
22 Oct - 13 Nov	Avianca
12 Oct - 28 Oct	Avianca
15 Oct - 31 Oct	Avianca
16 Oct - 31 Oct	Avianca
20 Oct - 22 Oct	Avianca
20 Oct - 23 Oct	Avianca
20 Oct - 24 Oct	Avianca
20 Oct - 26 Oct	Avianca
17 Oct - 01 Nov	Avianca
20 Oct - 17 Nov	Avianca
21 Oct - 18 Nov	Avianca
11 Oct - 01 Nov	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in October from $850

Return flights