AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in October 2025 (see full year).

Return flights

12 Oct - 18 Oct	Iberia	direct
29 Oct - 29 Nov	Iberia	direct
22 Oct - 20 Nov	Air Europa	direct
05 Oct - 11 Oct	Avianca
03 Oct - 19 Oct	Avianca
04 Oct - 20 Oct	Avianca
06 Oct - 13 Oct	Avianca
10 Oct - 26 Oct	Avianca
04 Oct - 22 Oct	Avianca
05 Oct - 22 Oct	Avianca
05 Oct - 23 Oct	Avianca
06 Oct - 23 Oct	Avianca
01 Oct - 01 Nov	Avianca
15 Oct - 06 Nov	Avianca
06 Oct - 27 Nov	Avianca
01 Oct - 03 Nov	Avianca
15 Oct - 15 Nov	Avianca
22 Oct - 22 Nov	Air Europa	direct
16 Oct - 06 Nov	Avianca
25 Oct - 04 Nov	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in October from $841

Return flights