Cheapest one-way flights from Mexico City to Santiago in December from $247

AirHint found the following cheapest one-way flights from Mexico City (MEX) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

29 Dec Avianca
31 Dec Copa
31 Dec Aeromexico direct
28 Dec Avianca
23 Dec Avianca
22 Dec Avianca
29 Dec LATAM Airlines Group direct
28 Dec LATAM Airlines Group direct
25 Dec LATAM Airlines Group direct
23 Dec Aeromexico direct

Also check the deals for return flights from Mexico City to Santiago in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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