AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 05 Dec	Copa
08 Dec - 23 Dec	Aeromexico	direct
03 Dec - 24 Dec	Aeromexico	direct
19 Dec - 26 Dec	Copa
03 Dec - 09 Dec	Avianca
01 Dec - 08 Dec	Avianca
01 Dec - 12 Dec	Aeromexico	direct
01 Dec - 09 Dec	Aeromexico	direct
09 Dec - 23 Dec	Aeromexico	direct
01 Dec - 11 Dec	Aeromexico	direct
17 Dec - 19 Jan	Avianca
17 Dec - 31 Jan	Avianca
15 Dec - 15 Jan	Avianca
27 Dec - 17 Jan	LATAM Airlines Group
22 Dec - 06 Jan	LATAM Airlines Group
27 Dec - 13 Jan	LATAM Airlines Group
25 Dec - 08 Jan	Copa
01 Dec - 08 Jan	Copa
16 Dec - 08 Jan	Copa
17 Dec - 08 Jan	Avianca

Also check the deals for one-way flights from Mexico City to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in December from $544

Return flights