AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in December 2025 (see full year).

Return flights

02 Dec - 15 Dec	Arajet
10 Dec - 30 Dec	Volaris
16 Dec - 21 Dec	Arajet
31 Dec - 30 Jan	Aeromexico	direct
11 Dec - 18 Dec	Viva Aerobus
16 Dec - 30 Dec	Arajet
11 Dec - 21 Dec	Arajet
09 Dec - 30 Dec	Aeromexico	direct
10 Dec - 30 Dec	Aeromexico	direct
02 Dec - 11 Dec	Copa
14 Dec - 31 Dec	Aeromexico	direct
28 Dec - 10 Jan	Arajet
22 Dec - 06 Jan	Aeromexico	direct
18 Dec - 08 Jan	Arajet
24 Dec - 06 Jan	Aeromexico	direct
26 Dec - 10 Jan	LATAM Airlines Group	direct
25 Dec - 10 Jan	LATAM Airlines Group
25 Dec - 10 Jan	LATAM Airlines Group	direct
18 Dec - 02 Jan	Arajet
19 Dec - 03 Jan	Avianca

Also check the deals for one-way flights from Mexico City to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Santiago in December from $552

Return flights