Cheapest one-way flights from Panama City to Madrid in October from $399

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

One-Way flights

09 Oct Avianca
19 Oct Avianca
21 Oct Avianca
31 Oct Avianca
25 Oct Avianca
07 Oct Avianca
05 Oct Avianca
22 Oct Avianca
24 Oct Avianca
01 Oct Avianca

Also check the deals for return flights from Panama City to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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