Cheapest one-way flights from Panama City to Madrid in October from $435

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

One-Way flights

12 Oct Turkish Airlines
29 Oct Turkish Airlines
24 Oct Turkish Airlines
18 Oct Turkish Airlines
06 Oct Turkish Airlines
11 Oct Turkish Airlines
30 Oct Turkish Airlines
31 Oct Avianca
06 Oct Air Europa direct
12 Oct Air Europa direct

Also check the deals for return flights from Panama City to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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