AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

27 Oct - 04 Nov	Turkish Airlines
25 Oct - 04 Nov	Avianca
25 Oct - 05 Nov	Avianca
21 Oct - 25 Oct	Air Europa	direct
02 Oct - 29 Nov	Air France
03 Oct - 11 Oct	Turkish Airlines
23 Oct - 28 Oct	Air France
05 Oct - 12 Oct	Air Europa	direct
08 Oct - 17 Oct	Air Europa	direct
22 Oct - 06 Nov	Air Europa	direct
30 Oct - 10 Nov	Avianca
05 Oct - 28 Oct	Air France
12 Oct - 26 Oct	Turkish Airlines
31 Oct - 04 Nov	Avianca
13 Oct - 20 Oct	Iberia	direct
25 Oct - 05 Nov	Iberia	direct
09 Oct - 16 Oct	Iberia	direct
12 Oct - 26 Oct	Air Europa	direct
31 Oct - 10 Nov	Avianca
17 Oct - 10 Nov	Avianca

Also check the deals for one-way flights from Panama City to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid

Cheapest return flights from Panama City to Madrid in October from $719

Return flights