Cheapest return flights from Panama City to Madrid in October from $643

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

25 Oct - 07 Nov Air Europa direct
20 Oct - 26 Oct Air Europa direct
20 Oct - 31 Oct Air Europa direct
19 Oct - 26 Oct Air Europa direct
24 Oct - 31 Oct Air Europa direct
30 Oct - 14 Nov Air Europa direct
15 Oct - 22 Oct Air Europa direct
15 Oct - 24 Oct Air Europa direct
28 Oct - 14 Nov Air Europa direct
21 Oct - 16 Nov Air Europa direct
18 Oct - 31 Oct Air Europa direct
13 Oct - 22 Oct Air Europa direct
13 Oct - 25 Oct Air Europa direct
28 Oct - 04 Nov Avianca
15 Oct - 30 Oct Air Europa direct
31 Oct - 17 Nov Avianca
27 Oct - 04 Nov Avianca
25 Oct - 04 Nov Avianca
26 Oct - 04 Nov Avianca
24 Oct - 11 Nov Avianca

Also check the deals for one-way flights from Panama City to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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