Cheapest return flights from Panama City to Madrid in October from $717

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2025 (see full year).

Return flights

15 Oct - 31 Oct Turkish Airlines
12 Oct - 26 Oct Avianca
31 Oct - 08 Nov Avianca
31 Oct - 10 Nov Avianca
17 Oct - 29 Oct Avianca
31 Oct - 11 Nov Avianca
01 Oct - 14 Oct Air France
17 Oct - 31 Oct Turkish Airlines
08 Oct - 21 Oct Turkish Airlines
18 Oct - 03 Nov Iberia direct
16 Oct - 23 Oct Iberia direct
08 Oct - 21 Oct Air Europa direct
24 Oct - 27 Oct Air Europa direct
20 Oct - 05 Nov Iberia direct
01 Oct - 15 Oct Turkish Airlines
21 Oct - 05 Nov Air Europa direct
22 Oct - 07 Nov Air France
31 Oct - 05 Nov Air Europa direct
31 Oct - 08 Nov Air Europa direct
11 Oct - 02 Nov KLM

Also check the deals for one-way flights from Panama City to Madrid in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid