AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in October 2026 (see full year).

Return flights

22 Oct - 29 Oct	Air France
06 Oct - 19 Oct	Air Europa	direct
06 Oct - 20 Oct	Air Europa	direct
01 Oct - 14 Oct	Air Europa	direct
01 Oct - 13 Oct	Air Europa	direct
07 Oct - 23 Oct	Iberia	direct
01 Oct - 15 Oct	Air Europa	direct
22 Oct - 29 Oct	Air Europa	direct
19 Oct - 04 Nov	Air Europa	direct
30 Oct - 10 Nov	Air Europa	direct
28 Oct - 10 Nov	Air Europa	direct
29 Oct - 10 Nov	Air Europa	direct
09 Oct - 30 Oct	Air Europa	direct
10 Oct - 30 Oct	Air France
31 Oct - 10 Nov	Air Europa	direct

Also check the deals for one-way flights from Panama City to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in October from $602

Return flights